With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40117-63-3,Quinuclidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.
Step 1. Quinuclidin-4-ylmethanol Quinuclidine-4-carboxylic acid hydrochloride (6.0 g, 0.03 1 mmoles) in tetrahydrofuran (300 ml) was treated with lithium aluminum hydride (5.0 g, 0.137 mmoles) at ambient temperature for 18 hours. Water (20 ml) and 10% aqueous sodium hydroxide (7.5 ml) was added carefully and the mixture filtered, washing with diethyl ether. The combined filtrates were evaporated to dryness to give the title compound as a white solid 4.04 g, (91%): MS (+ve ion electrospray) m/z 142 (MH+, 100%)
40117-63-3 Quinuclidine-4-carboxylic acid hydrochloride 66737825, aquinuclidine compound, is more and more widely used in various.
Reference£º
Patent; SmithKline Beecham p.l.c.; US6281226; (2001); B1;,
Quinuclidine – Wikipedia
Quinuclidine | C7H13N | ChemSpider