A new synthetic route of Quinuclidine-4-carbonitrile

This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26458-78-6,Quinuclidine-4-carbonitrile,its application will become more common.

A common heterocyclic compound, 26458-78-6,Quinuclidine-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 26458-78-6

Quinuclidine-4-carbonitrile (4 g, 29.4 mmol) was treated with 30 mL of 6 N aqueous HCl solution and stirred under reflux for 16 hr. The reaction mixture was cooled and evaporated to dryness under reduced pressure. The solid obtained was triturated with 20% ether-hexane to afford the HCl salt of quinuclidine-4-carboxylic acid (5.5 g, quantitative).

This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26458-78-6,Quinuclidine-4-carbonitrile,its application will become more common.

Reference£º
Patent; CoMentis, Inc.; BILCER, Geoffrey M.; NG, Raymond; (104 pag.)US2016/9706; (2016); A1;,
Quinuclidine – Wikipedia
Quinuclidine | C7H13N | ChemSpider