123536-14-1, In an article, published in an article,authors is Buergi, Justus J., once mentioned the application of 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride,molecular formula is C7H16Cl2N2, is a conventional compound. this article was the specific content is as follows.
Fluorescent Agonists of the alpha7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine
Here, we investigated whether fluorescence labeled small molecule agonists of the alpha7 nicotinic acetylcholine receptor (nAChR) might be identified to enhance receptor studies. Enantiomerically pure 3-amino-quinuclidines appended with fluorophores at the 3-amino group were synthesized and tested by electrophysiology on human alpha7 nAChR in Xenopus oocytes, uncovering (R)-4 and (R)-9 as the first examples of fluorescent alpha7 nAChR agonists. These molecules elegantly incorporate the fluorescent reporter group as part of the pharmacophore itself and provide a new class of tool compounds for the study of these ligand-gated ion channels.
If you are interested in 123536-14-1, you can contact me at any time and look forward to more communication. 123536-14-1
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H139N | ChemSpider