One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Quinuclidin-3-yl acetate, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Ehlert, mentioned the application of 827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2
Comparison of the muscarinic receptor binding activity of some tertiary amines and their quaternary ammonium analogues
A series of tertiary amines and their N-methyl quaternary salts were examined for their ability to inhibit specific [3H]3-quinuclidinyl benzilate binding to rat brain muscarinic receptors. The more flexible tertiary amines, like dimethylaminoethyl acetate, were less potent than their respective quaternary ammonium analogues, while rigid tertiary amines, like aceclidine, were more potent than their quaternary derivatives. The competition curves of most of the compounds were adequately described by a two-site binding equation. A good correlation between pharmacological activity and the high-affinity dissociation constant was observed. The influence of pH in the competitive inhibition of [3H]3-quinuclidinyl benzilate binding by arecoline and scopolamine was also examined. The potency of these amines declined relative to that of their N-methyl derivatives as the pH increased from 8.90 to 9.0, suggesting that it is primarily the protonated form of arecoline and scopolamine which interacts with the muscarinic receptor.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H56N | ChemSpider