One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of (R)-3-Aminoquinuclidine dihydrochloride, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, while maintaining the compound’s other desirable pharmacological properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series (1h, 1o, 2a, 9a, and 18a) shows an improved hERG safety profile over PNU-282,987.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. Application In Synthesis of (R)-3-Aminoquinuclidine dihydrochloride, In my other articles, you can also check out more blogs about Application In Synthesis of (R)-3-Aminoquinuclidine dihydrochloride
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H156N | ChemSpider