123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, belongs to quinuclidine compound, is a common compound. Product Details of 123536-14-1In an article, once mentioned the new application about 123536-14-1.
Copper-Catalyzed Carboxylation of C-F Bonds with CO2
An effective Cu-catalyzed selective formal carboxylation of C-F bonds with an atmospheric pressure of CO2 is reported. A variety of gem-difluoroalkenes, gem-difluorodienes, and alpha-trifluoro-methyl alkenes show high reactivity and selectivity for this ipso monocarboxylation. Under mild conditions, diverse important alpha-fluoroacrylic acids and alpha,alpha-difluorocarboxylates are obtained in good-to-high yields. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and the resulting products are readily converted into bioactive alpha-fluorinated carbonyl compounds, indicating potential application in biochemistry and drug discovery. Mechanistic studies reveal that fluorinated boronate esters might be vital intermediates in this transformation.
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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H160N | ChemSpider