123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, belongs to quinuclidine compound, is a common compound. category: quinuclidineIn an article, once mentioned the new application about 123536-14-1.
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists
Human alpha7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the synthesis and agonistic activities of a series of indolizine derivatives targeting to alpha7 nAChR. The results show that all synthesized compounds have affinity to alpha7 nAChR and some give strong agonistic activity, particularly most active agonists show higher potency than control EVP-6124. The docking and structure-activity relationship studies provide insights to develop more potent novel alpha7 nAChR agonists.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H159N | ChemSpider