Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 3,7-Dimethylocta-2,6-dienal, 5392-40-5, Name is 3,7-Dimethylocta-2,6-dienal, SMILES is C/C(C)=CCC/C(C)=C/C=O, belongs to quinuclidines compound. In a document, author is Nordvall, G, introduce the new discover.
3-(2-benzofuranyl)quinuclidin-2-ene derivatives: Novel muscarinic antagonists
A series of 26 derivatives of the novel muscarinic antagonist 3-(2-benzofuranyl) quinuclidin-2-ene (1) has been synthesized and evaluated for muscarinic and antimuscarinic properties. The affinity of the compounds was determined by competition experiments in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[H-3]-3-quinuclidinyl benzilate as the radioligand, and the antimuscarinic potency was determined in a functional assay on isolated guinea pig urinary bladder using carbachol as the agonist. The 5-fluorobenzofuranyl derivative was slightly more potent than 1. The 7-bromo-substituted 8 displayed a 14-fold tissue selectivity ratio for muscarinic receptors in the cortex versus the parotid gland. Comparative molecular field analysis and quantitative structure-activity relationship models were developed for this series of substituted benzofuranyl derivatives.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5392-40-5. Recommanded Product: 3,7-Dimethylocta-2,6-dienal.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider