871-91-0, Name is 7-Octyn-1-ol, molecular formula is C8H14O, Application In Synthesis of 7-Octyn-1-ol, belongs to quinuclidines compound, is a common compound. In a patnet, author is Naito, Ryo, once mentioned the new application about 871-91-0.
Research and Development of Solifenacin for the Treatment of Overactive Bladder (OAB)
Solifenacin succinate (Vesicare (R)), a novel muscarinic receptor antagonist for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency, has been approved in more than 60 countries. In the course of continuing efforts to develop potent and bladder-selective muscarinic M-3 receptor antagonists, solifenacin was designed as one of conformationally restricted analogues of quinuclidin-3-yl benzhydrylcarbamate with little selectivity among muscarinic receptor subtypes. In preclinical studies, solifenacin exhibited a highly bladder-selective profile compared with other antimuscarinic agents. Clinically, solifenacin ameliorates all symptoms in OAB patients; and, in particular, it produces a significant decrease in urgency episodes, which is the principal symptom of OAB with good tolerability. In this article, the drug discovery and the process development of solifenacin succinate are described.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 871-91-0 help many people in the next few years. Application In Synthesis of 7-Octyn-1-ol.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider