Chemistry is an experimental science, Recommanded Product: 1,3-Dimethyladamantane, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 702-79-4, Name is 1,3-Dimethyladamantane, molecular formula is C12H20, belongs to quinuclidines compound. In a document, author is Nomoto, F.
A practical chemoenzymatic process to access (R)-quinuclidin-3-ol on scale
(+/-)-3-Butyryloxyquinuclidinium butyrate 6 (2 M, 571 g/L), prepared from (+/-)-quinuclidin-3-ol 1 and butyric anhydride, undergoes enantioselective hydrolysis by an Aspergillus melleus protease {1.0% (w/v)} in water in the presence of Ca(OH)(2) to keep the reaction at pH 7 and trap butyric acid that is introduced as part of (+/-)-6 and generated by the enzymatic hydrolysis. After a 24 h period, extraction with n-heptane provides (R)-quinuclidin-3-yl butyrate 5a, which, on methanolysis with Na2CO3, is converted into (R)-1, a common pharmacophore of neuromodulators acting on muscarinic receptors, in 96% ee and 42% overall yield from (+/-)-1. The unwanted antipode (S)-1, which is extracted into n-butanol and purified via its hydrochloride salt in 89% ee and 40% overall yield from (+/-)-1, can be racemized by the catalysis of Raney Co at 140degreesC under an atmosphere of H, (5 kg/cm(2)) to regenerate (+/-)-1 in 97% yield. (C) 2003 Elsevier Science Ltd. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 702-79-4, in my other articles. Recommanded Product: 1,3-Dimethyladamantane.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider