Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 13623-94-4, Name is 1,1-Bis(methylthio)-2-nitroethylene, molecular formula is C4H7NO2S2, belongs to quinuclidines compound, is a common compound. In a patnet, author is Nordvall, G, once mentioned the new application about 13623-94-4, Formula: C4H7NO2S2.
3-(2-benzofuranyl)quinuclidin-2-ene derivatives: Novel muscarinic antagonists
A series of 26 derivatives of the novel muscarinic antagonist 3-(2-benzofuranyl) quinuclidin-2-ene (1) has been synthesized and evaluated for muscarinic and antimuscarinic properties. The affinity of the compounds was determined by competition experiments in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[H-3]-3-quinuclidinyl benzilate as the radioligand, and the antimuscarinic potency was determined in a functional assay on isolated guinea pig urinary bladder using carbachol as the agonist. The 5-fluorobenzofuranyl derivative was slightly more potent than 1. The 7-bromo-substituted 8 displayed a 14-fold tissue selectivity ratio for muscarinic receptors in the cortex versus the parotid gland. Comparative molecular field analysis and quantitative structure-activity relationship models were developed for this series of substituted benzofuranyl derivatives.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 13623-94-4. The above is the message from the blog manager. Formula: C4H7NO2S2.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider