Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 112-80-1, Name is Oleic acid, molecular formula is C18H34O2, belongs to quinuclidines compound, is a common compound. In a patnet, author is McDonald, Ivar M., once mentioned the new application about 112-80-1, SDS of cas: 112-80-1.
Discovery of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor agonists
High throughput screening led to the identification of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to be potent and selective. Poor brain penetrance in this series was attributed to transporter-mediated efflux, which was in turn due to high pK(a). A novel 4-fluoroquinuclidine significantly lowered the pK(a) of the quinuclidine moiety, reducing efflux as measured by a Caco-2 assay. (C) 2013 Elsevier Ltd. All rights reserved.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 112-80-1. The above is the message from the blog manager. SDS of cas: 112-80-1.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider