Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 53293-00-8, Name is 5-Hexynoic acid, SMILES is C#CCCCC(O)=O, belongs to quinuclidines compound. In a document, author is Niphade, Navnath C., introduce the new discover, HPLC of Formula: C6H8O2.
Efficient and single pot process for the preparation of enantiomerically pure solifenacin succinate, an antimuscarinic agent
The development of an efficient and economic one-pot process, in which the configuration of the chiral centers of the starting materials is retained, for the preparation of highly pure solifenacin succinate, an antimuscarinic agent, is presented in this communication. The earlier reported processes suffer from the drawbacks of racemization and low yields due to the use of strong base, higher temperatures, and longer reaction times. The present work circumvents these issues by activating (3R)-quinuclidin-3-ol into a mixed active carbonate derivative by treating it with bis(4-nitrophenyl)carbonate. The subsequent reaction of the active carbonate with an enantiomerically pure amine without using any base at ambient temperature provided enantiomerically pure solifenacin with an overall yield of 90%.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 53293-00-8 is helpful to your research. HPLC of Formula: C6H8O2.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider