Chemistry, like all the natural sciences, Application In Synthesis of (E)-4-methoxy-4-oxobut-2-enoic acid, begins with the direct observation of nature¡ª in this case, of matter.2756-87-8, Name is (E)-4-methoxy-4-oxobut-2-enoic acid, SMILES is O=C(O)/C=C/C(OC)=O, belongs to quinuclidines compound. In a document, author is Gu, Jianhui, introduce the new discover.
Convenient new synthesis of umeclidinium bromide
Umeclidinium bromide, a drug used for chronic obstructive pulmonary disease, is synthesized through a new intermediate of phenyl(quinuclidin-4-yl)methanone. This novel method with simple operation flow and cheap reagents, makes it suitable for scale up. The overall four-step process provides umeclidinium bromide in 29% yield and the purity up to 99.83%. The X-ray crystal structure of the drug molecule was first reported.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 2756-87-8. Application In Synthesis of (E)-4-methoxy-4-oxobut-2-enoic acid.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider