Application of 5390-04-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 5390-04-5, Name is 4-Pentyn-1-ol, SMILES is C#CCCCO, belongs to quinuclidines compound. In a article, author is McDonald, Ivar M., introduce new discover of the category.
Discovery of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor agonists
High throughput screening led to the identification of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to be potent and selective. Poor brain penetrance in this series was attributed to transporter-mediated efflux, which was in turn due to high pK(a). A novel 4-fluoroquinuclidine significantly lowered the pK(a) of the quinuclidine moiety, reducing efflux as measured by a Caco-2 assay. (C) 2013 Elsevier Ltd. All rights reserved.
Application of 5390-04-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5390-04-5.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider