Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 25952-53-8, Name is 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, molecular formula is C8H18ClN3, belongs to quinuclidines compound. In a document, author is Naito, Ryo, introduce the new discover, Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride.
Research and Development of Solifenacin for the Treatment of Overactive Bladder (OAB)
Solifenacin succinate (Vesicare (R)), a novel muscarinic receptor antagonist for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency, has been approved in more than 60 countries. In the course of continuing efforts to develop potent and bladder-selective muscarinic M-3 receptor antagonists, solifenacin was designed as one of conformationally restricted analogues of quinuclidin-3-yl benzhydrylcarbamate with little selectivity among muscarinic receptor subtypes. In preclinical studies, solifenacin exhibited a highly bladder-selective profile compared with other antimuscarinic agents. Clinically, solifenacin ameliorates all symptoms in OAB patients; and, in particular, it produces a significant decrease in urgency episodes, which is the principal symptom of OAB with good tolerability. In this article, the drug discovery and the process development of solifenacin succinate are described.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 25952-53-8. Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider