Application In Synthesis of 2,2,4-Trimethyl-1,3-pentanediol 1-monoisobutyrate, New discoveries in chemical research and development in 2021. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 25265-77-4, Name is 2,2,4-Trimethyl-1,3-pentanediol 1-monoisobutyrate, SMILES is CC(C(C(C)(COC(C(C)C)=O)C)O)C.CC(C)C(OC(C(C)C)C(C)(C)CO)=O, belongs to quinuclidine compound. In a article, author is Brown, GR, introduce new discover of the category.
Optimised quinuclidine squalene synthase (SQS) inhibitors are reported; 3-[2-(2-allyl-4-(2-ethoxy carbonylethyl)phenyl)ethynyl]quinuclidin-3-ol 1c, is a potent inhibitor of rat (KI = 6 nM) and human (KI = 43 nM) microsomal SQS; the oral ED(50) of 1c, for the inhibition of rat cholesterol biosynthesis was 1.3+/-0.45 mg/kg and for the R-enantiomer 1m, 0.8+/-0.2 mg/kg, with the corresponding R-carboxylic acid 6a, being 0.9+/-0.25 mg/kg. (C) 1997 Elsevier Science Ltd. All rights reserved.
Because enzymes can increase reaction rates by enormous factors, typically producing only a single product in quantitative yield, they are the focus of active research.In my other articles, you can also check out more blogs about 25265-77-4. Application In Synthesis of 2,2,4-Trimethyl-1,3-pentanediol 1-monoisobutyrate.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider