When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In a document, author is Macor, JE, introducing its new discovery. Category: quinuclidines.
A direct, short chiral synthesis of the selective 0 nicotinic receptor agonist (-)-spiro[l-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one] (AR-R17779) is presented. The key step utilized attack of the dianion of the (R)-HYTRA ester [(R)-(+)-2-hydroxy-1,2,2-triphenylethyl acetate] on quinuclidin-3-one, followed by a selective precipitation of the diasteriomeric tertiary alcohol that led to (S)-(-)-AR-R17779 in two additional steps.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 116-31-4 Category: quinuclidines.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider