Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. Like 101-39-3, Name is α-Methyl-trans-cinnamaldehyde. In a document, author is McDonald, Ivar M., introducing its new discovery. Electric Literature of 101-39-3.
High throughput screening led to the identification of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to be potent and selective. Poor brain penetrance in this series was attributed to transporter-mediated efflux, which was in turn due to high pK(a). A novel 4-fluoroquinuclidine significantly lowered the pK(a) of the quinuclidine moiety, reducing efflux as measured by a Caco-2 assay. (C) 2013 Elsevier Ltd. All rights reserved.
Electric Literature of 101-39-3, I am very proud of our efforts over the past few months and hope to 101-39-3 help many people in the next few years.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider