The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate, is researched, Molecular C14H8BF4Rh, CAS is 36620-11-8, about Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium-Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib, the main research direction is carbocyclic heterocyclic amine enantioselective synthesis ligand catalyzed hydrogenation enamide; Tofacitinib enantioselective synthesis Rhodium bisphosphorus ligand catalyzed hydrogenation enamide; P ligands; asymmetric hydrogenation; enamides; stereoelectronic effects; tofacitinib.Quality Control of Bis(norbornadiene)rhodium (I) tetrafluoroborate.
We herein report the development of a conformationally defined, electron-rich, C2-sym., P-chiral bisphosphorus ligand, ArcPhos, by taking advantage of stereoelectronic effects in ligand design. With the Rh-ArcPhos catalyst, excellent enantioselectivities and unprecedentedly high turnovers (TON up to 10,000) were achieved in the asym. hydrogenation of aliphatic carbocyclic and heterocyclic tetrasubstituted enamides, to generate a series of chiral cis-2-alkyl-substituted carbocyclic and heterocyclic amine derivatives in excellent enantiomeric ratios. This method also enabled an efficient and practical synthesis of the Janus kinase inhibitor (R)-tofacitinib.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider