Day: March 29, 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yuan, Jing; Liu, Chong; Chen, Yan; Zhang, Zhenfeng; Yan, Deyue; Zhang, Wanbin researched the compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ).Formula: C14H8BF4Rh.They published the article 《Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones》 about this compound( cas:36620-11-8 ) in Tetrahedron. Keywords: indanone preparation rhodium catalyst intramol hydroacylation disubstituted alkene. We’ll tell you more about this compound (cas:36620-11-8).

The intramol. hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of addnl. substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asym. version was not considered possible due to problems associated with the racemization of the products. The authors have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramol. hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asym. variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.

Here is a brief introduction to this compound(36620-11-8)Formula: C14H8BF4Rh, if you want to know about other compounds related to this compound(36620-11-8), you can read my other articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate(SMILESS: [F-][B+3]([F-])([F-])[F-].C12=C3[Rh+]14567(C8=C5C9C6=C7C8C9)C%10=C4C2CC3%10,cas:36620-11-8) is researched.Application of 616-14-8. The article 《A practical strategy to access chiral α-aryloxy carboxylic acids through ion-pairing directed asymmetric hydrogenation》 in relation to this compound, is published in Organic Chemistry Frontiers. Let’s take a look at the latest research on this compound (cas:36620-11-8).

A series of optically active α-aryloxy carboxylic acids I [R1 = n-Bu, 2-furyl, 4-F3CC6H4, etc.; R2 = H, 4-ClC6H4, 4-PhC6H4, etc.] was obtained via Chenphos/Rh catalyzed highly efficient asym. hydrogenation. The proposed ion-pairing interaction between ligand and substrate played a vital role in achieving high enantioselectivity.

Here is a brief introduction to this compound(36620-11-8)Application In Synthesis of Bis(norbornadiene)rhodium (I) tetrafluoroborate, if you want to know about other compounds related to this compound(36620-11-8), you can read my other articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Application In Synthesis of Bis(norbornadiene)rhodium (I) tetrafluoroborate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate, is researched, Molecular C14H8BF4Rh, CAS is 36620-11-8, about Structural exploration of rhodium catalysts and their kinetic studies for efficient parahydrogen-induced polarization by side arm hydrogenation. Author is Itoda, Marino; Naganawa, Yuki; Ito, Makoto; Nonaka, Hiroshi; Sando, Shinsuke.

Parahydrogen-induced polarization (PHIP) is a rapid and cost-effective hyperpolarization technique using transition metal-catalyzed hydrogenation with parahydrogen. We examined rhodium catalysts and their kinetic studies, rarely considered in the research of current PHIP. It emerged that rhodium complexes with electron-donating bisphosphine ligands, with a dicyclohexylphosphino group, appear to be more effective than conventional rhodium catalysts.

Here is a brief introduction to this compound(36620-11-8)Application In Synthesis of Bis(norbornadiene)rhodium (I) tetrafluoroborate, if you want to know about other compounds related to this compound(36620-11-8), you can read my other articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Recommanded Product: Bis(norbornadiene)rhodium (I) tetrafluoroborate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate, is researched, Molecular C14H8BF4Rh, CAS is 36620-11-8, about A Computational Study of Asymmetric Hydrogenation of 2-Phenyl Acrylic Acids Catalyzed by a Rh(I) Catalyst with Ferrocenyl Chiral Bisphosphorus Ligand: The Role of Ion-Pair Interaction. Author is Fan, Xiangru; Zheng, Lini; Yang, Yuhong; Dong, Xiu-Qin; Zhang, Xumu; Chung, Lung Wa.

Asym. hydrogenation reaction is one of the most efficient synthetic methods to form useful chiral compounds for synthetic chem., medicinal chem. and material chem. Generally, the enantioselectivity of many hydrogenation reactions is controlled by steric hindrance between the chiral ligand and substrate. Recently, Zhang group developed a highly asym. hydrogenation of 2-aryl and 2-alkyl acrylic acids catalyzed by a Rh(I) catalyst with a chiral Wudaphos ligand. The excellent enantioselectivity of this asym. reaction was proposed to be controlled by ion-pair interaction between the substrate and chiral ligand. In this study, a systematic d. functional theory study has been carried out to investigate the reaction mechanism and origin of the enantioselectivity. Our computational results suggest that this reaction follows the classic mechanism involving oxidative addition of H2, migratory insertion and reductive elimination. Different from the C=C coordination to the metal in the common oxidative addition step, our study found that the chelation of the carboxyl group of the substrate to the cationic Rh(I) metal is more favorable in this oxidative addition step. The high enantioselectivity is proposed to be dictated by a better catalyst/substrate geometric complementarity in the major pathway to have less distortion of the catalyst for a strong ion-pair interaction.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Scalable Asymmetric Synthesis of MK-8998, a T-type Calcium Channel Antagonist, published in 2022-02-18, which mentions a compound: 36620-11-8, mainly applied to scalable MK 8998 preparation enantioselective calcium channel antagonist, Application of 36620-11-8.

Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochem. relied on either chiral rhodium catalyst-mediated asym. hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider