So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Xian; Liu, Song; Wang, Quanjun; Zhou, Gang; Yao, Lin; Ouyang, Qin; Jiang, Ru; Lan, Yu; Chen, Weiping researched the compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ).Application of 36620-11-8.They published the article 《Highly Regio- and Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids》 about this compound( cas:36620-11-8 ) in Organic Letters. Keywords: unsaturated acid enantioselective synthesis hydrogenation Trifer catalyst complex; enantioselective hydrogenation conjugated dienoic acid Trifer catalyst complex. We’ll tell you more about this compound (cas:36620-11-8).
Highly regio- and enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted γ,δ-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.
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Quinuclidine – Wikipedia,
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