So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Yingguo; Majhi, Pankaj Kumar; Song, Runjiang; Mou, Chengli; Hao, Lin; Chai, Huifang; Jin, Zhichao; Chi, Yonggui Robin researched the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ).Application of 1214711-48-4.They published the article 《Carbene-Catalyzed Dynamic Kinetic Resolution and Asymmetric Acylation of Hydroxyphthalides and Related Natural Products》 about this compound( cas:1214711-48-4 ) in Angewandte Chemie, International Edition. Keywords: carbene catalyzed dynamic kinetic resolution asym acylation hydroxyphthalide; N-heterocyclic carbenes; chirality; kinetic resolution; natural products; organocatalysis. We’ll tell you more about this compound (cas:1214711-48-4).
A catalytic dynamic kinetic resolution and asym. acylation reaction of hydroxyphthalides is developed [e.g., o-carboxybenzaldehyde (in equilibrium with hydroxyphthalide) + Me 4-formylbenzoate → I (96%, 98:2 e.r.) in presence of chiral NHC precatalyst]. The reaction involves formation of a carbene catalyst derived chiral acyl azolium intermediate that effectively differentiates the two enantiomers of racemic hydroxyphthalides. The method allows quick access to enantiomerically enriched phthalidyl esters with proven applications in medicine. It also enables asym. modification of natural products and other functional mols. that contain acetal/ketal groups, such as corollosporine and fimbricalyxlactone C.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider