The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Electric Literature of C14H8BF4Rh.Liu, Xian; Wen, Jialin; Yao, Lin; Nie, Huifang; Jiang, Ru; Chen, Weiping; Zhang, Xumu published the article 《Highly Chemo- and Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids》 about this compound( cas:36620-11-8 ) in Organic Letters. Keywords: oxo alkenoic acid chemoselective enantioselective hydrogenation rhodium josiphos; chiral keto acid stereoselective preparation. Let’s learn more about this compound (cas:36620-11-8).
The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodol. was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen.
There is still a lot of research devoted to this compound(SMILES：[F-][B+3]([F-])([F-])[F-].C12=C3[Rh+]14567(C8=C5C9C6=C7C8C9)C%10=C4C2CC3%10)Electric Literature of C14H8BF4Rh, and with the development of science, more effects of this compound(36620-11-8) can be discovered.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider