The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Product Details of 1214711-48-4.Wu, Zijun; Wang, Jian published the article 《Enantioselective Medium-Ring Lactone Synthesis through an NHC-Catalyzed Intramolecular Desymmetrization of Prochiral 1,3-Diols》 about this compound( cas:1214711-48-4 ) in ACS Catalysis. Keywords: enantioselective cyclization intramol desymmetrization prochiral diol heterocyclic carbene catalyst; lactone preparation. Let’s learn more about this compound (cas:1214711-48-4).
A highly enantioselective intramol. annulation reaction of 1,3-diols catalyzed by a triazolium N-heterocyclic carbene (NHC) precatalyst is disclosed, affording the corresponding medium-sized lactones in moderate to good yields with high enantioselectivities. It is worth noting that this compatible catalytic system was successfully applied to assemble a broad range of chiral medium-sized lactones, including ones with eight-, nine-, ten-, eleven-, and twelve-membered rings.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider