The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Product Details of 36620-11-8.Tao, Lin; Zhao, Qingyang; Zhang, Xumu; Dong, Xiu-Qin published the article 《Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation》 about this compound( cas:36620-11-8 ) in Chinese Chemical Letters. Keywords: chromane preparation enantioselective; chromanylidene acetate asym hydrogenation rhodium catalyst. Let’s learn more about this compound (cas:36620-11-8).
Rh/ZhaoPhos-catalyzed asym. hydrogenation of a series of (E)-2-(chroman-4-ylidene)acetates I (R = H, Cl, F, MeO; R1 = CO2Me, CO2Et, CO2iPr) was successfully developed to prepare various chiral 4-substituted chromanes II with high yields and excellent enantioselectivities (up to 99% yield, 98% ee). Moreover, the gram-scale hydrogenation could be performed well in the presence of 0.02 mol% catalyst loading (TON = 5000) and the hydrogenation product II (R = H, R1 = CO2Et) was easily converted to access other important compounds, II (R = H, R1 = CO2H, CH2OH) which demonstrated the synthetic utility of this asym. catalytic methodol.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider