So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gandi, Vasudeva Rao; Doan, Bao Nguyen Do; Kasinathan, Sivarajan; Bates, Roderick W. researched the compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ).HPLC of Formula: 36620-11-8.They published the article 《Stereocontrol in the synthesis of cyclic amino acids: A new ligand for directed hydrogenation through hydrogen bonding》 about this compound( cas:36620-11-8 ) in Organic & Biomolecular Chemistry. Keywords: Lincomycin hygric acid synthesis hydrogenation; Argatroban pipecolic acid synthesis; cyclic amino acid diastereoselective synthesis ligand hydrogenation hydrogen bond; hydrogenation reaction mechanism DFT free energy; aminobutenol alkylation allyl halide ring closing metathesis hydrogenation. We’ll tell you more about this compound (cas:36620-11-8).
A system for the directed hydrogenation of nitrogen heterocycles is described in which hydrogen is delivered cis to a hydroxymethyl group by a rhodium catalyst with a simple phosphine ligand. The chem. is applied to the synthesis of the hygric acid moiety of Lincomycin and the pipecolic acid moiety of Argatroban. A series of control experiments indicate that the stereoselectivity is a result of a combination of both coordination and hydrogen bonding.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider