The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Product Details of 36620-11-8.Cai, Nengjian; Mi, Fen; Wu, Yanmei; Song, Hao; Liu, Xiao-Yu; Qin, Yong published the article 《Practical and efficient preparation of the chiral 4-bromotryptophan derivative by Rh-catalyzed hydrogenation》 about this compound( cas:36620-11-8 ) in Tetrahedron Letters. Keywords: bromotryptophan enantioselective preparation rhodium catalyzed asym hydrogenation bromoindole. Let’s learn more about this compound (cas:36620-11-8).
An efficient three-step sequence has been developed for the preparation of a chiral 4-bromotryptophan derivative starting from the com. available 4-bromoindole. Key to the synthesis was the generation of the chiral center via a Rh-catalyzed asym. hydrogenation of a dehydrotryptophan precursor with 95% yield and >99% ee. Notably, the whole synthetic route required no column chromatog. operations and was readily conducted on large scales.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider