The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Recommanded Product: Bis(norbornadiene)rhodium (I) tetrafluoroborate.Decultot, Ludovic; Policarpo, Rocco L.; Wright, Brandon A.; Huang, Danny; Shair, Matthew D. published the article 《Asymmetric total synthesis of C9′-epi-sinefungin》 about this compound( cas:36620-11-8 ) in ChemRxiv. Keywords: epi sinefungin modular scalable asym synthesis. Let’s learn more about this compound (cas:36620-11-8).
The natural nucleoside (+)-sinefungin, structurally similar to cofactor S-adenosyl-L-methionine (SAM), inhibits various SAM-dependent methyltransferases (MTs). Access to sinefungin analogs could serve as the basis for the rational design of small-mol. methyltransferase inhibitors. We developed a route to the unnatural C9′ epimer of sinefungin that employed a diastereoselective Overman rearrangement to install the key C6′ amino stereocenter. The ability for late stage modification is highlighted, opening an avenue for the discovery of new MTs inhibitors.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider