In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Practical and efficient preparation of the chiral 4-bromotryptophan derivative by Rh-catalyzed hydrogenation, published in 2020-02-13, which mentions a compound: 36620-11-8, mainly applied to bromotryptophan enantioselective preparation rhodium catalyzed asym hydrogenation bromoindole, Formula: C14H8BF4Rh.
An efficient three-step sequence has been developed for the preparation of a chiral 4-bromotryptophan derivative starting from the com. available 4-bromoindole. Key to the synthesis was the generation of the chiral center via a Rh-catalyzed asym. hydrogenation of a dehydrotryptophan precursor with 95% yield and >99% ee. Notably, the whole synthetic route required no column chromatog. operations and was readily conducted on large scales.
This literature about this compound(36620-11-8)Formula: C14H8BF4Rhhas given us a lot of inspiration, and I hope that the research on this compound(Bis(norbornadiene)rhodium (I) tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider