The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.SDS of cas: 36620-11-8.Yang, Jiaxin; Li, Xiuxiu; You, Cai; Li, Shuailong; Guan, Yu-Qing; Lv, Hui; Zhang, Xumu published the article 《Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds》 about this compound( cas:36620-11-8 ) in Organic & Biomolecular Chemistry. Keywords: chiral cyclic lactone lactam ketone preparation enantioselective; exocyclic unsaturated carbonyl compound hydrogenation rhodium catalyst. Let’s learn more about this compound (cas:36620-11-8).
A highly enantioselective hydrogenation of exocyclic α,β-unsaturated carbonyl compounds I (X = O, CH2, N-Boc; L = bond, CH2; R = Ph, 4-MeOC6H4, 2-naphthyl, etc.) catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) has been developed, giving the corresponding α-chiral cyclic lactones, lactams and ketones II with high yields and excellent enantioselectivities (up to 99% yield and 99% ee). Remarkably, the hydrogen bond between the substrate and the catalyst plays a critical role in this transformation. The synthetic utility of this protocol has been demonstrated by efficient synthesis of chiral 3-(4-fluorobenzyl)piperidine, a key chiral fragment of bioactive mols.
As far as I know, this compound(36620-11-8)SDS of cas: 36620-11-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider