So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wheeler, Philip; Vora, Harit U.; Rovis, Tomislav researched the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ).HPLC of Formula: 1214711-48-4.They published the article 《Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals》 about this compound( cas:1214711-48-4 ) in Chemical Science. Keywords: enantioselective alpha fluoroamide preparation unsaturated aldehyde amine hydrochloride; diastereoselective alpha fluoroamide synthesis enantioenriched amine alpha fluoroenal reactant; nitrogen heterocyclic carbene catalyst redox amidation alpha fluoroamide preparation; amide functionalization amine fluorohydrin preparation enantioenrichment retention. We’ll tell you more about this compound (cas:1214711-48-4).
The scope of the NHC-redox amidation has been expanded to include a variety of α,β-unsaturated aldehydes, including α-fluoro α,β-unsaturated aldehydes, which give rise to enantioenriched α-fluoroamides in good to excellent yield and enantioselectivity (up to 97% ee). Enantioenriched amines may be elaborated to either diastereomer of the product in high diastereoselectivity (up to 99 : 1). Functionalization of the amide products to amines and fluorohydrins is also demonstrated with retention of enantioenrichment at the fluorine stereocenter.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider