The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Formula: C14H8BF4Rh.Edelstein, Emma K.; Rankic, Danica A.; Dudley, Caroline C.; McMinn, Spencer E.; Adpressa, Donovon A. published the article 《Synthesis of proline analogs via Rh-catalyzed asymmetric conjugate addition》 about this compound( cas:36620-11-8 ) in ACS Catalysis. Keywords: substituted proline enantioselective diastereoselective synthesis solvent effect; dehydroproline boronic acid asym conjugate addition reaction rhodium catalyst; proline substituted free energy DFT. Let’s learn more about this compound (cas:36620-11-8).
An enantio- and diastereoselective Rh-catalyzed conjugate addition reaction for the synthesis of proline analogs is reported. A high-throughput experimentation campaign was used to identify an efficient chiral catalyst which was able to afford the desired products in high yield and with high levels of diastereo- and enantioselectivity. This method was used to afford a range of 3-substituted proline derivatives from readily available dehydroproline electrophiles and boronic acid nucleophiles.
Although many compounds look similar to this compound(36620-11-8)Formula: C14H8BF4Rh, numerous studies have shown that this compound(SMILES:[F-][B+3]([F-])([F-])[F-].C12=C3[Rh+]14567(C8=C5C9C6=C7C8C9)C%10=C4C2CC3%10), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider