The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ) is researched.Computed Properties of C14H8BF4Rh.Decultot, Ludovic; Policarpo, Rocco L.; Wright, Brandon A.; Huang, Danny; Shair, Matthew D. published the article 《Asymmetric total synthesis of C9′-epi-sinefungin》 about this compound( cas:36620-11-8 ) in ChemRxiv. Keywords: epi sinefungin modular scalable asym synthesis. Let’s learn more about this compound (cas:36620-11-8).
The natural nucleoside (+)-sinefungin, structurally similar to cofactor S-adenosyl-L-methionine (SAM), inhibits various SAM-dependent methyltransferases (MTs). Access to sinefungin analogs could serve as the basis for the rational design of small-mol. methyltransferase inhibitors. We developed a route to the unnatural C9′ epimer of sinefungin that employed a diastereoselective Overman rearrangement to install the key C6′ amino stereocenter. The ability for late stage modification is highlighted, opening an avenue for the discovery of new MTs inhibitors.
Although many compounds look similar to this compound(36620-11-8)Computed Properties of C14H8BF4Rh, numerous studies have shown that this compound(SMILES:[F-][B+3]([F-])([F-])[F-].C12=C3[Rh+]14567(C8=C5C9C6=C7C8C9)C%10=C4C2CC3%10), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider