The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Synthetic Route of C18H13BCl3F4N3O.Wen, Genfa; Su, Yingpeng; Zhang, Guoxiang; Lin, Qiqiao; Zhu, Yujin; Zhang, Qianqian; Fang, Xinqiang published the article 《Stereodivergent Synthesis of Chromanones and Flavanones via Intramolecular Benzoin Reaction》 about this compound( cas:1214711-48-4 ) in Organic Letters. Keywords: aldehyde aryl ketoalkoxy racemic triazolium intramol benzoin reaction catalyst; chromanone stereoselective preparation; flavanone stereoselective preparation. Let’s learn more about this compound (cas:1214711-48-4).
The strategy of stereodivergent reactions on racemic mixtures (stereodivergent RRM) was employed for the first time in intramol. benzoin reactions and led to the rapid access of chromanones/flavanones with two consecutive stereocenters. The easily separable stereoisomers of the products were obtained with moderate to excellent enantioselectivities in a single step. Catechol type additives proved crucial in achieving the desired diastereo- and enantioselectivities.
Although many compounds look similar to this compound(1214711-48-4)Synthetic Route of C18H13BCl3F4N3O, numerous studies have shown that this compound(SMILES:ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider