Discover the magic of the 36620-11-8

After consulting a lot of data, we found that this compound(36620-11-8)Product Details of 36620-11-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene, published in 2021-03-19, which mentions a compound: 36620-11-8, mainly applied to amino fluoro methylpiperidine enantioselective regioselective chemoselective green preparation scaleup; tetrasubstituted fluoroalkene hydrogenation rhodium catalyst, Product Details of 36620-11-8.

The development of multi kilo-gram scale green and economical synthetic route of enantiomerically pure cis-4-amino-3-fluoro-1-methylpiperidine I was described. The synthesis featured a highly regio-, chemo- and enantioselective asym. hydrogenation of N-benzyl-4-((tert-butoxycarbonyl)amino)-5-fluoro-tetrahydropyridinium chloride. No purification or chiral enrichment was necessary due to high selectivity resulting from proper selection of catalyst system Rh(NBD)2(BF4) and Walphos 003. The crude product N-benzyl piperidine was carried directly to N-methylpiperidine utilizing a highly effective one-pot debenzylation and reductive amination protocol. The target compound 1•2HCl was prepared in 66-68% overall yield with >99% ee and >98.5% purity from available compound 3-fluoropyridin-4-amine with a Process Mass Intensity of 150.

After consulting a lot of data, we found that this compound(36620-11-8)Product Details of 36620-11-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider