Downstream Synthetic Route Of 1214711-48-4

After consulting a lot of data, we found that this compound(1214711-48-4)Synthetic Route of C18H13BCl3F4N3O can be used in many types of reactions. And in most cases, this compound has more advantages.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1214711-48-4, is researched, Molecular C18H13BCl3F4N3O, about Oxidative Enantioselective α-Fluorination of Aliphatic Aldehydes Enabled by N-Heterocyclic Carbene Catalysis, the main research direction is fluoroester chemoselective enantioselective preparation; chemoselective enantioselective oxidative fluorination aliphatic aldehyde alc indenooxazinotriazolium catalyst; N-heterocyclic carbenes; aldehydes; enolates; fluorine; oxidation.Synthetic Route of C18H13BCl3F4N3O.

In the presence of the indenooxazinotriazolium carbene precursor I•BF4-, aliphatic aldehydes such as hydrocinnamaldehydes 4-RC6H4CH2CH2CHO (R = H, Br) underwent chemo- and enantioselective oxidative fluorination with N-fluorobenzenesulfonimide (NFSI) with alcs. such as cyclohexanol to give nonracemic α-fluoroesters such as II in 71-89% yields and in 73-98% ee. II (R = H) was hydrolyzed to its parent acid, converted to an N-benzyl-β-fluoroamine, and reduced to a β-fluoro alc.; II (R = Br) underwent Suzuki coupling to give II (R = Ph).

After consulting a lot of data, we found that this compound(1214711-48-4)Synthetic Route of C18H13BCl3F4N3O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider