Gong, Leyi; Parnes, Howard published the artcile< Synthesis of the 3H-labeled 4-HT3 antagonist (RS-25259-197) at high specific activity>, Recommanded Product: (S)-3-Amino-1-azabicyclo[2.2.2]octane, the main research area is RS 25259 197 tritium label preparation; tritiation RS 25259 197.
The preparation of the title compound, a selective 5-HT3 antagonist with antiemetic properties, was described. The key intermediate was 6-bromo-1,2-dihydronaphthoic acid, which was synthesized from 4-bromophenylacetic acid by Michael addition, acid-induced ring cyclization, reduction and dehydration. The compound 6-bromo-1,2-dihydronaphthoic acid was selected because it has two labeling sites to ensure high specific activity of the final product. Reduction of 6-bromo-1,2-dihydronaphthamide with carrier-free tritium gas, followed by reduction of the amide functional group with BF3-OEt2 and intramol. cyclization furnished the title compound having a specific activity of 70.4 Ci/mmol and >99% purity.
Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Tritiation. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Recommanded Product: (S)-3-Amino-1-azabicyclo[2.2.2]octane.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider