Austin, Wesley F.; Hubbs, Jed L.; Fuller, Nathan O.; Creaser, Steffen P.; McKee, Timothy D.; Loureiro, Robyn M. B.; Findeis, Mark A.; Tate, Barbara; Ives, Jeffrey L.; Bronk, Brian S. published the artcile< SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold>, Application In Synthesis of 120570-05-0, the main research area is SAR gamma secretase modulator scaffold black cohosh amyloid.
In this communication we present details of our analog efforts within a novel series of gamma-secretase modulating compounds Esters and carbamates were investigated as bioisosteres for a glycoside moiety present in an initial hit isolated from black cohosh extract We identified elements within each series that retain the potency and selectivity of the initial lead while improving physicochem. properties.
MedChemComm published new progress about Anti-Alzheimer agents. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Application In Synthesis of 120570-05-0.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider