Kowalczyk, Bruce A. published the artcile< Total synthesis of RS-42358 and analogs using lateral lithiation>, Quality Control of 120570-05-0, the main research area is benzisoquinolinone preparation; RS 42358 preparation.
A short synthesis of the 5-HT3 receptor antagonist RS-42358 was developed based on the condensation of 5,6-dihydro-1H,4H-naphtho[1,8-cd]pyran-1-one (I) with S-3-aminoquinuclidine. The position 2 analogs of RS-42358 were made by condensing various primary amines with I. The key step in the synthesis of I was lateral lithiation of N,N-diethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide using BuLi in THF.
Synthesis published new progress about Lithiation. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Quality Control of 120570-05-0.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider