Demian, Iulia; Gripshover, David F. published the artcile< Enantiomeric purity determination of 3-aminoquinuclidine by diastereomeric derivatization and high-performance liquid chromatographic separation>, Related Products of 120570-05-0, the main research area is aminoquinuclidine enantiomer resolution HPLC; liquid chromatog aminoquinuclidine enantiomer resolution; benzoyltartaric anhydride chiral derivatization aminoquinuclidine resolution.
Four different diastereomeric derivatization methods were used for the HPLC and TLC separation of 3-aminoquinuclidine enantiomers. The chiral reagents used were S(-)-1-phenylethyl isocyanate, R(-)-1-naphthylethyl isocyanate, 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate, and the anhydrides of R,R(+)- and S,S(-)-O,O-dibenzoyltartaric acid (DBTAA). The TLC separations were carried out on silica gel plates; the HPLC used a Zorbax C8 and Zorbax Sil phase. All diastereomeric derivatives were strong UV absorbers at 254 nm. The best separation was achieved by HPLC with DBTAA, which allowed detection of the minor enantiomer down to 10-3 enantiomeric ratio.
Journal of Chromatography published new progress about Chromatographic chiral resolution. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Related Products of 120570-05-0.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider