Odzak, Renata; Primozic, Ines; Tomic, Srdanka published the artcile< 3-amidoquinuclidine derivatives: synthesis and interaction with butyrylcholinesterase>, Electric Literature of 120570-05-0, the main research area is aminoquinuclidine acid anhydride condensation; amidoquinuclidine preparation benzyl bromide alkylation; racemic enantiopure quaternary amidoquinuclidine preparation; butyrylcholinesterase inhibitor quaternary amidoquinuclidine.
Racemates as well as (R)- and (S)-enantiomers of 3-pivalamidoquinuclidine I (R = Me3C) and 3-acetamidoquinuclidine I (R = Me) were prepared Their quaternary racemic and enantiomerically pure N-benzyl derivatives II (R = Me3C, Me) were synthesized as well. I and II were tested as substrates and inhibitors of butyrylcholinesterase (BChE) from horse serum (EC 3.1.1.8). No hydrolysis was observed under the exptl. conditions applied. On the contrary, inhibition of BChE by (R)- and (S)-enantiomers of II (R = Me3C) was observed II (R = Me3C) with Ki = 41.57 μmol dm-3 was a 3-fold more potent inhibitor than the (R)-enantiomer. On the other hand, preliminary results indicated that both enantiomers of II (R = Me) may possibly be inhibitors as well as activators depending on the concentrations of benzoylcholine (BzCh) used as a substrate of BChE.
Croatica Chemica Acta published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Electric Literature of 120570-05-0.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider