Day: October 14, 2022

Ni, Zhi-Jie; Barsanti, Paul; Brammeier, Nathan; Diebes, Anthony; Poon, Daniel J.; Ng, Simon; Pecchi, Sabina; Pfister, Keith; Renhowe, Paul A.; Ramurthy, Savithri; Wagman, Allan S.; Bussiere, Dirksen E.; Le, Vincent; Zhou, Yasheen; Jansen, Johanna M.; Ma, Sylvia; Gesner, Thomas G. published the artcile< 4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors>, Computed Properties of 120570-05-0, the main research area is aminobenzimidazolylquinolinone preparation CHK1 inhibitor; quinolinone amino benzimidazolyl preparation CHK1 inhibitor.

CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(aminoalkylamino)-3-benzimidazolyl-2-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed a synergistic effect with a DNA-damaging agent, camptothecin.

Bioorganic & Medicinal Chemistry Letters published new progress about Cell cycle. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Computed Properties of 120570-05-0.

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Kowalczyk, Bruce A.; Rohloff, John C.; Dvorak, Charles A.; Gardner, John O. published the artcile< Improved preparation of (R)- and (S)-3-aminoquinuclidine dihydrochloride>, Application In Synthesis of 120570-05-0, the main research area is quinuclidine amino hydrochloride preparation.

An improved procedure for the synthesis of either (R)- or (S)-3-aminoquinuclidine was developed. Key intermediate imine (I) was made in a one pot process using lithium oxide as the base and mol. sieves.

Synthetic Communications published new progress about 120570-05-0. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Application In Synthesis of 120570-05-0.

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider