Day: October 18, 2022

Demian, Iulia; Gripshover, David F. published the artcile< High-performance liquid chromatographic determination of enantiomeric purity of 1-methyl-3-pyrrolidinol via derivatization with (R,R)-O,O-dibenzoyltartaric acid anhydride>, Application In Synthesis of 120570-05-0, the main research area is methylpyrrolidinol enantiomeric purity determination HPLC; liquid chromatog methylpyrrolidinol enantiomeric purity; benzoyltartaric acid anhydride derivatization methylpyrrolidinol.

The enantiomeric purity of 1-methyl-3-pyrrolidinol was determined by its diastereomeric derivatization with (R,R)-O,O-dibenzoyltartaric acid anhydride followed by reversed-phase HPLC separation with UV detection. The column used was packed with Zorbax C8, and the mobile phase was 50:50 MeOH-0.1% triethylamine solution (pH 4.2).

Journal of Chromatography published new progress about 120570-05-0. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Application In Synthesis of 120570-05-0.

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Koltun, Elena; Richards, Steven; Chan, Vicky; Nachtigall, Jason; Du, Hongwang; Noson, Kevin; Galan, Adam; Aay, Naing; Hanel, Art; Harrison, Amanda; Zhang, Jeff; Won, Kwang-Ai; Tam, Danny; Qian, Fawn; Wang, Tao; Finn, Patricia; Ogilvie, Kathleen; Rosen, Jon; Mohan, Raju; Larson, Christopher; Lamb, Peter; Nuss, John; Kearney, Patrick published the artcile< Discovery of a new class of glucosylceramide synthase inhibitors>, Product Details of C7H14N2, the main research area is glucosylceramide synthase inhibitor heterocycle preparation SAR.

A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochem. and cellular potency as well as ADME properties led to compound 23c (I). Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about Diabetes mellitus. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Product Details of C7H14N2.

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Janetka, James W.; Almeida, Lynsie; Ashwell, Susan; Brassil, Patrick J.; Daly, Kevin; Deng, Chun; Gero, Thomas; Glynn, Roberta E.; Horn, Candice L.; Ioannidis, Stephanos; Lyne, Paul; Newcombe, Nicholas J.; Oza, Vibha B.; Pass, Martin; Springer, Stephanie K.; Su, Mei; Toader, Dorin; Vasbinder, Melissa M.; Yu, Dingwei; Yu, Yan; Zabludoff, Sonya D. published the artcile< Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors>, Computed Properties of 120570-05-0, the main research area is ureido thiophene carboxamide preparation checkpoint kinase inhibitor SAR.

Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Computed Properties of 120570-05-0.

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider