Janetka, James W.; Almeida, Lynsie; Ashwell, Susan; Brassil, Patrick J.; Daly, Kevin; Deng, Chun; Gero, Thomas; Glynn, Roberta E.; Horn, Candice L.; Ioannidis, Stephanos; Lyne, Paul; Newcombe, Nicholas J.; Oza, Vibha B.; Pass, Martin; Springer, Stephanie K.; Su, Mei; Toader, Dorin; Vasbinder, Melissa M.; Yu, Dingwei; Yu, Yan; Zabludoff, Sonya D. published the artcile< Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors>, Computed Properties of 120570-05-0, the main research area is ureido thiophene carboxamide preparation checkpoint kinase inhibitor SAR.
Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.
Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Computed Properties of 120570-05-0.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider