Koltun, Elena; Richards, Steven; Chan, Vicky; Nachtigall, Jason; Du, Hongwang; Noson, Kevin; Galan, Adam; Aay, Naing; Hanel, Art; Harrison, Amanda; Zhang, Jeff; Won, Kwang-Ai; Tam, Danny; Qian, Fawn; Wang, Tao; Finn, Patricia; Ogilvie, Kathleen; Rosen, Jon; Mohan, Raju; Larson, Christopher; Lamb, Peter; Nuss, John; Kearney, Patrick published the artcile< Discovery of a new class of glucosylceramide synthase inhibitors>, Product Details of C7H14N2, the main research area is glucosylceramide synthase inhibitor heterocycle preparation SAR.
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochem. and cellular potency as well as ADME properties led to compound 23c (I). Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about Diabetes mellitus. 120570-05-0 belongs to class quinuclidine, and the molecular formula is C7H14N2, Product Details of C7H14N2.
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider