Li, Qiong’s team published research in Macromolecular Research in 28 | CAS: 1761-71-3

Macromolecular Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Li, Qiong published the artcilePreparation of Non-Planar-Ring Epoxy Thermosets Combining Ultra-Strong Shape Memory Effects and High Performance, Application In Synthesis of 1761-71-3, the publication is Macromolecular Research (2020), 28(5), 480-493, database is CAplus.

Non-planar-ring epoxies together with non-planar-ring hardeners could achieve thermosets combining ultra-high shape recovery speed and excellent thermal properties. High shape recovery speed reflected high efficiency and could decrease the energy consumption and the harmful effect of external stimuli on the materials, while it often conflicts with the thermal properties of shape memory polymers. In this paper, for the first time, epoxy resins with the super-short shape recovery time within 3 s were developed from non-planar-ring epoxies and hardeners and their glass transition temperature (Tg) were ∼127°C much higher than their benzene ring analogs. The effects of non-planar-ring structures of the epoxies and hardeners on the curing behavior, thermal properties as well as the shape memory properties of the thermosets were systematically investigated; the structure-property relationships were disclosed with the help of computational simulation of structure parameters and ESP maps. The faster shape recovery speed of the non-planar-ring epoxy thermosets is from their higher mol. mobility contributed by the conformational transition of non-planar-rings as well as their higher recovery force compared with benzene ring analogs. Their higher Tgs are from the steric hindrance by the larger mol. volume of the non-planar-rings than benzene ring. This work will provide an effective method to produce shape memory polymers with excellent shape memory effects and high performance.

Macromolecular Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Murrell, Emily’s team published research in ACS Combinatorial Science in 22 | CAS: 1353016-70-2

ACS Combinatorial Science published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Murrell, Emily published the artcileIncorporation of fluorine into an OBOC peptide library by copper-free Click chemistry toward the discovery of PET imaging agents, Related Products of quinuclidine, the publication is ACS Combinatorial Science (2020), 22(3), 109-113, database is CAplus and MEDLINE.

A one-bead one-compound (OBOC) library of peptide-based imaging agents was developed where a 19F-containing moiety was added onto the N-terminus of octamer peptides through copper-free Click chem. prior to screening of the library. This created a library of complete imaging agents that was screened against CXCR4, a receptor of interest for cancer imaging. The screen directly resulted in the discovery of a peptide-based imaging agent with an IC50 of 138μM. This proof-of-concept study describes a new type of OBOC peptide library design, where hits discovered from screening can be easily translated into their fluorine-18 counterpart for PET imaging without loss of affinity.

ACS Combinatorial Science published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Coburn, Craig A.’s team published research in ChemMedChem in 7 | CAS: 20029-52-1

ChemMedChem published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Coburn, Craig A. published the artcileDiscovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3), Application In Synthesis of 20029-52-1, the publication is ChemMedChem (2012), 7(1), 123-133, database is CAplus and MEDLINE.

TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channels have the capacity to regulate the activity of neuronal pathways by influencing the resting membrane potential of neurons on which they are expressed. The central nervous system (CNS) expression of these channels suggests potential roles in neurol. disorders, and it is believed that the development of TASK-3 antagonists could lead to the therapeutic treatment of a number of neurol. conditions. While a therapeutic potential for TASK-3 channel modulation exists, there are only a few documented examples of potent and selective small-mol. channel blockers. Herein is described the discovery and lead optimization efforts for a novel series of TASK-3 channel antagonists based on a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine high-throughput screening lead from which a subseries of potent and selective inhibitors were identified. One compound, I, was profiled in detail with respect to its phys. properties and demonstrated pharmacol. target engagement as indicated by its ability to modulate sleep architecture in rodent EEG telemetry models.

ChemMedChem published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Wang, Ting’s team published research in Journal of Coatings Technology and Research in 18 | CAS: 1761-71-3

Journal of Coatings Technology and Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H10N2S, Product Details of C13H26N2.

Wang, Ting published the artcileMethanol degradation mechanisms and permeability phenomena in novolac epoxy and polyurethane coatings, Product Details of C13H26N2, the publication is Journal of Coatings Technology and Research (2021), 18(3), 831-842, database is CAplus.

On a global scale, methanol is one of the most important feedstocks and is used widely as solvent and co-solvent. However, due to the polar nature and associated ability to conduct current, the small mol. can take part in galvanic corrosion of metal storage tanks and degrade the barrier properties of protective coatings. In the present work, we investigated the degradation of two novolac epoxy coatings and a polyurethane (PU) coating exposed to methanol with the aim of quantifying the various degradation paths. Absorption and desorption rates were measured and the thermomech. properties followed by dynamic mech. anal. For evaluation of the coating barrier properties (i.e., breakthrough time and steady state permeation rates of methanol), permeation cells were applied. During methanol absorption, simultaneous leaching of certain coating ingredients and bonding of methanol to the binder matrix via hydrogen bonds was evidenced. In terms of classification, the bonding of methanol took place by two types of mechanisms. In Type I, the methanol mol. forms a single hydrogen bond to the coating network, thereby acting as a plasticizer, which decreases the coating storage modulus and glass transition temperature For Type II bonding of methanol, on the other hand, two hydrogen bonds to the coating network form per mol., resulting in so-called phys. crosslinking. The Type I mechanism boosted segmental mobility and contributed to the leaching of the plasticizer benzyl alc. from the novolac epoxy coatings and residual solvents (i.e., naphtha and xylene) from the PU coating. Following the methanol desorption, and attributed to an increased effective crosslinking d. from Type II bound methanol, the novolac epoxy and PU coatings exhibited significant increases in the glass transition temperatures In addition, for the three coatings, a gradual decline in the permeability rate of methanol was observed over time. These enhanced (and unexpected) barrier properties result from a combination of effects ascribed to Type II bound methanol and the leaching process.

Journal of Coatings Technology and Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H10N2S, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Peterson, Luke J.’s team published research in Organic Letters in 19 | CAS: 1160556-64-8

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Peterson, Luke J. published the artcileSynthesis of Cyclic Guanidines Bearing N-Arylsulfonyl and N-Cyano Protecting Groups via Pd-Catalyzed Alkene Carboamination Reactions, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Organic Letters (2017), 19(11), 2817-2820, database is CAplus and MEDLINE.

Palladium-catalyzed carboamination reactions of N-allylguanidines bearing cleavable N-cyano or N-arylsulfonyl protecting groups are described. The reactions afford cyclic guanidine products, e.g. I [Q = CN, Ts], in good yield, and transformations of substrates bearing internal alkenes proceed with high diastereoselectivity. Deuterium labeling studies indicate these transformations proceed via anti-aminopalladation pathways.

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Wang, Yanfang’s team published research in ACS Biomaterials Science & Engineering in 6 | CAS: 1353016-70-2

ACS Biomaterials Science & Engineering published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C15H23BO2, Quality Control of 1353016-70-2.

Wang, Yanfang published the artcileDouble Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells, Quality Control of 1353016-70-2, the publication is ACS Biomaterials Science & Engineering (2020), 6(2), 1074-1089, database is CAplus and MEDLINE.

Sequence-defined lipo-oligomers generated via solid-phase assisted synthesis have been developed as siRNA delivery systems for RNA-interference (RNAi) based gene silencing. Here, novel siRNA lipo-polyplexes were established, which were postmodified with monovalent or bivalent DBCO-PEG24 agents terminated with peptide GE11 (YHWYGYTPQNVI) for epidermal growth factor receptor (EGFR)-targeted siRNA delivery into EGFR-pos. tumor cells. Lipo-oligomers containing eight cationizable succinoyltetraethylene-pentamine (Stp) units mediated higher siRNA nanoparticle core stability than those containing four Stp units, and the incorporation of histidines for enhanced endosomal buffer capacity resulted in an improved gene silencing efficiency. Lipo-polyplexes modified with monovalent or bivalent PEG-GE11 via the copper-free click reaction possessed significantly enhanced cellular internalization and transfection efficiency in EGF receptor-pos. human cervical KB and hepatoma Huh7 cells in comparison with the corresponding lipo-polyplexes shielded with PEG24 without targeting. Furthermore, modification with the bivalent DBCO-PEG24-GE11 ligand resulted in higher gene silencing efficiency than modification with the same equivalent of the monovalent DBCO-PEG24-GE11 ligand.

ACS Biomaterials Science & Engineering published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C15H23BO2, Quality Control of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Kumar, Amit’s team published research in European Journal of Organic Chemistry in 2021 | CAS: 1761-71-3

European Journal of Organic Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Kumar, Amit published the artcileCatalytic Hydrogenation of Urea Derivatives and Polyureas, Product Details of C13H26N2, the publication is European Journal of Organic Chemistry (2021), 2021(32), 4546-4550, database is CAplus.

Herein the catalytic hydrogenation of various urea derivatives RNHC(O)NHR (R = Ph, 3,4-dichlorophenyl, cyclohexyl, benzyl, etc.) to amines RNH2 and methanol has been presented. The reaction is catalyzed by a ruthenium or an iridium Macho pincer complex and produces amine and methanol in very good to excellent yields. Moreover, this concept is also expanded to demonstrate the first example of the hydrogenative depolymerization of polyureas I to produce diamines II and methanol in moderate yields.

European Journal of Organic Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Shi, Ting’s team published research in Nanomaterials in 10 | CAS: 1761-71-3

Nanomaterials published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C3H5F3O, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Shi, Ting published the artcileIonic liquids-containing silica microcapsules: a potential tunable platform for shaping-up epoxy-based composite materials?, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Nanomaterials (2020), 10(5), 881, database is CAplus and MEDLINE.

In this work, silica microcapsules containing phosphonium ionic liquid (IL), denoted SiO2@IL, were successfully synthesized for the first time using the one step sol-gel method in IL/H20 emulsion. The morphologies of the obtained micron-size microcapsules, including their diameter distribution, were characterized using dynamic light scattering (DLS), SEM, and transmission electron microscopy (TEM). The thermal behavior of these microcapsules and the mass fraction of the encapsulated IL in the silica microcapsules were determined using thermogravimetric anal., showing an excellent thermal stability (up to 220°C) and highlighting that an amount of 20 weight% of IL is contained in the silica microcapsules. In a second step, SiO2@IL microcapsules (1 weight%) were dispersed into epoxy-amine networks to provide proof of concept of the ability of such microcapsules to act as healing agents as microcracks propagate into the epoxy networks.

Nanomaterials published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C3H5F3O, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Zhang, Niu-niu’s team published research in MedChemComm in 9 | CAS: 20029-52-1

MedChemComm published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C7H13BrSi, Computed Properties of 20029-52-1.

Zhang, Niu-niu published the artcileDesign, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents, Computed Properties of 20029-52-1, the publication is MedChemComm (2018), 9(8), 1293-1304, database is CAplus and MEDLINE.

A series of m-amidophenol derivatives, e.g., I and II, were designed and synthesized. Their antitubercular activities were evaluated in vitro against M. tuberculosis strains H37Ra and H37Rv and clin. isolated multidrug-resistant M. tuberculosis strains. Ten compounds displayed minimal inhibitory concentrations (MICs) against M. tuberculosis H37Ra below 2.5μg mL-1 and compound I was the most active compound (MIC = 0.625μg mL-1). Compounds I and II also showed potent inhibitory activity against M. tuberculosis H37Rv (MIC = 0.39 γ mL-1) and several clin. isolated multidrug-resistant M. tuberculosis strains (MIC = 0.39-3.125μg mL-1). The compounds did not show inhibitory activity against normal Gram-pos. and Gram-neg. bacteria. They exhibited low cytotoxicity against HepG2 and RAW264.7 cell lines. The results demonstrated m-amidophenol as an attractive scaffold for the development of new antitubercular agents.

MedChemComm published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C7H13BrSi, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Tian, Zong-Qiang’s team published research in Bioorganic & Medicinal Chemistry in 12 | CAS: 795299-77-3

Bioorganic & Medicinal Chemistry published new progress about 795299-77-3. 795299-77-3 belongs to quinuclidine, auxiliary class Azetidine,Amine, name is 2-(Azetidin-1-yl)ethanamine, and the molecular formula is C19H21N3O3S, Safety of 2-(Azetidin-1-yl)ethanamine.

Tian, Zong-Qiang published the artcileSynthesis and biological activities of novel 17-aminogeldanamycin derivatives, Safety of 2-(Azetidin-1-yl)ethanamine, the publication is Bioorganic & Medicinal Chemistry (2004), 12(20), 5317-5329, database is CAplus and MEDLINE.

Geldanamycin interferes with the action of heat shock protein 90 (Hsp90) by binding to the N-terminal ATP binding site and inhibiting an essential ATPase activity. In a program directed toward finding potent, water soluble inhibitors of Hsp90, we prepared a library of over sixty 17-alkylamino-17-demethoxygeldanamycin analogs, and compared their affinity for Hsp90, ability to inhibit growth of SKBr3 mammalian cells, and in selected cases, water solubility Over 20 analogs showed cell growth inhibition potencies similar to that of 17-allylamino-17-demethoxygeldanamycin (17-AAG), the front-runner geldanamycin analog that is currently in multiple clin. trials. Many of these analogs showed water solubility properties that were desirable for formulation. One of the most potent and water-soluble analogs in the series was 17-(2-dimethylaminoethyl)amino-17-demethoxygeldanamycin (17-DMAG), which was independently prepared by the NCI and will soon enter clin. trials. Importantly, the binding affinity of these analogs to the mol. target Hsp90 does not correlate well with their cytotoxicity in SKBr3 cells.

Bioorganic & Medicinal Chemistry published new progress about 795299-77-3. 795299-77-3 belongs to quinuclidine, auxiliary class Azetidine,Amine, name is 2-(Azetidin-1-yl)ethanamine, and the molecular formula is C19H21N3O3S, Safety of 2-(Azetidin-1-yl)ethanamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider