Dufresne, Claude published the artcileSynthesis of Montelukast (MK-0476) Metabolic Oxidation Products, Related Products of quinuclidine, the publication is Journal of Organic Chemistry (1996), 61(24), 8518-8525, database is CAplus.
Chem. synthesis of six oxidized derivatives of MK-0476 (Montelukast, L-706631), which have been key tools in the identification of its metabolites is reported. Three diastereoisomeric pairs I (R1 = H, OH; R2 = H, OH; R3 = Me, CH2OH) of potential oxidative metabolites of MK-0476, starting from the (S)-hydroxy ester II in 10 and five steps, and starting from MK-0476 itself in one step have been prepared In one case the key benzylic hydroxyl was introduced by a bromination and saponification reaction sequence. In another case, the key step was the addition of a hydroxymethyl carbanion equivalent on ketone. The two sulfoxides were prepared by a direct oxidation of MK-0476 with m-chloroperbenzoic acid.
Journal of Organic Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider