McNelles, Stuart A. published the artcileRapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne-Azide Cycloaddition, Formula: C19H15NO3, the publication is Macromolecules (Washington, DC, United States) (2017), 50(20), 7993-8001, database is CAplus.
Preparation of structurally perfect high-generation dendrimer libraries with different peripheral groups is challenging as divergent synthesis introduces peripheral defects and convergent synthesis leads to low yields. Here, we prepare a third-generation polyester dendron based on the bisMPA monomer structure, having eight peripheral azide functionalities, as an “inner” dendron. We also prepare a series of low-generation “outer” dendrons (G2 and G3) with various peripheral groups, including aromatic, aliphatic, and polar structures, each having a single dibenzoazacyclooctyne (DIBAC) at the core. Efficient strain-promoted azide-alkyne cycloaddition (SPAAC) enables quant. coupling between the outer and inner dendrons, producing high-generation (G5 and G6) dendrimers in a single coupling step. Characterization by NMR and mass spectrometry shows that the coupling products are structurally perfect. Using this strategy, we prepared a small dendrimer library that includes the first high-generation monodisperse peripherally PEGylated dendrimers as well as a structure bearing bulky protected amino acids at its periphery. This general strategy allows for rapid, efficient, and quant. preparation of high-generation dendrimers with a variety of peripheral and core functional groups, starting from small, easily prepared fragments.
Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider