Day: November 21, 2022

Fujisawa, Yuta published the artcileMechanically Robust, Self-Healable Polymers Usable under High Humidity: Humidity-Tolerant Noncovalent Cross-Linking Strategy, COA of Formula: C13H26N2, the publication is Journal of the American Chemical Society (2021), 143(37), 15279-15285, database is CAplus and MEDLINE.

Although mech. robust polymer materials had not been thought to self-heal, we recently found that poly(ether thiourea) PTUEG₃, which is a glassy polymer with high mech. strength, self-heals even at ambient temperatures This finding updated the above preconception. Nevertheless, it should also be noted that PTUEG₃, under high humidity, absorbs water and is plasticized to lose its mech. strength. Humidity-induced plasticization is a general problem for polymers with polar groups. Herein, we report that PTUEG₃, if designed by copolymerization to contain only 10 mol % of a dicyclohexylmethane (Cy₂M) thiourea unit (TUCy₂M), serves as a humidity-tolerant, mech. robust polymer material that can self-heal at ambient temperatures This copolymer contained, in its ether thiourea (TUEG₃)-rich domain, a humidity-tolerant, noncovalently cross-linked 3D network with mech. robustness formed by stacking of the Cy₂M group. The present work provides a promising design strategy for mech. robust, self-healable polymers usable under high humidity.

Journal of the American Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Flood, Dillon T. published the artcileExpanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Journal of the American Chemical Society (2019), 141(25), 9998-10006, database is CAplus and MEDLINE.

DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity, the idiosyncratic and hydrophilic nature of the DNA tag severely limits the scope of applicable chemistries. It is known that biomacromols. can be reversibly, noncovalently adsorbed and eluted from solid supports, and this phenomenon has been utilized to perform synthetic modification of biomols. in a strategy we have described as reversible adsorption to solid support (RASS). Herein, we present the adaptation of RASS for a DEL setting, which allows reactions to be performed in organic solvents at near anhydrous conditions opening previously inaccessible chem. reactivities to DEL. The RASS approach enabled the rapid development of C(sp²)-C(sp³) decarboxylative cross-couplings with broad substrate scope, an electrochem. amination (the first electrochem. synthetic transformation performed in a DEL context), and improved reductive amination conditions. The utility of these reactions was demonstrated through a DEL-rehearsal in which all newly developed chemistries were orchestrated to afford a compound rich in diverse skeletal linkages. We believe that RASS will offer expedient access to new DEL reactivities, expanded chem. space, and ultimately more drug-like libraries.

Journal of the American Chemical Society published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kumar, I. V. Sunil published the artcileIdentification, synthesis and characterization of impurities of Montelukast sodium, Related Products of quinuclidine, the publication is Asian Journal of Chemistry (2011), 23(10), 4536-4546, database is CAplus.

Montelukast sodium is a selective leukotriene receptor antagonist [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] which inhibits cysteinyl leukotriene CysLT₁ receptor. Various synthesis methods of Montelukast have been published. During laboratory optimization and later in-bulk synthesis, the formation of various impurities was detected. Besides, a Pharma Europa draft mentions nine process-related impurities. However, the method of preparation of most of these impurities is not available in the literature. Also, different route of synthesis will have different impurity profile and those process related impurities are not covered in pharmacopeia issues. In this study the authors report the synthesis of possible process impurities and the target compounds thus formed include several impurities previously mentioned in Pharma Europa.

Asian Journal of Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sliozberg, Yelena published the artcileInterface binding and mechanical properties of MXene-epoxy nanocomposites, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Composites Science and Technology (2020), 108124, database is CAplus.

Thermosetting epoxy polymers exhibit excellent stiffness and strength and are commonly utilized as matrixes to make fiber reinforced composites. However, epoxy thermosets are brittle and typically possess a low fracture toughness that restricts their applications. One promising mechanism for improving mech. properties of epoxy is the integration of micro- and nano-scale fillers. MXenes, a large family of 2D transition-metal carbides, carbonitrides, and nitrides, can be used to produce multifunctional polymer nanocomposites due to their excellent elec., thermal, and mech. properties. We employed d. functional theory and coarse-grained mol. dynamics simulations to evaluate binding energy and microscopic mechanisms of fracture under uniaxial tension for MXene-epoxy composites. The simulation results were verified by manufacturing Ti₃C₂Tx MXene-epoxy composites and studying their structure and fracture surfaces. Binding between Ti₃C₂Tx and epoxy becomes stronger with less hydrogen coverage of Ti₃C₂Tx surface due to increase in favorable electrostatic interactions. At higher filler contents, the increase of the modulus is reduced due to filler aggregation. Void formation was detected near edges of the particles in MXene-epoxy composites under deformation from both exptl. and simulation studies of the fracture surfaces. From these observations, we expect the MXene fillers to improve epoxy toughness and enhance its mech. performance.

Composites Science and Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C11H8N2O2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rehman, Sheikh published the artcileDevelopment of new graphene/epoxy nanocomposites and study of cure kinetics, thermal and mechanical properties, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Thermochimica Acta (2020), 178785, database is CAplus.

New graphene/polymer nanocomposites were prepared using graphene nanoplatelets (GNPs) and the epoxy system Epilok 60-566/Curamine 32-494. The GNPs were first dispersed into the curamine hardener using bath ultrasonication, followed by the addition of the epoxy resin. The cure kinetics were studied by DSC under non-isothermal and under isothermal conditions. The kinetic parameters of the curing process were determined using the non-isothermal Kissinger and Ozawa-Flynn-Wall models. The degree of curing increased with the addition of GNPs, while the activation energy decreased by 13.7% for the primary amine reaction and by 6.6% for the secondary amine reaction with epoxy groups as obtained from Kissinger. An increase in thermal stability by the addition of GNPs was identified in the range of 360-580° using TGA. In terms of mech. properties, addition of an optimum amount of 0.5% weight of GNPs in the hardener improved the Young’s Modulus by 37%. Nanoindentation measurements showed 9.4% improvement in hardness at 0.7% weight

Thermochimica Acta published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Gruzdev, M. S. published the artcileSynthesis and study of vitrescent materials based on the alkoxybenzoic acids derivatives and triethanolamine, COA of Formula: C13H16O2, the publication is Russian Journal of General Chemistry (2013), 83(4), 652-658, database is CAplus.

Alkoxybenzoic, benzyloxybenzoic, cyclohexylbenzoic, and benzoic acid triesters of triethanolamine (RCOOCH₂CH₂)₃N [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 3, 4, 6, 9, 12] (I) were prepared as potential liquid crystalline compounds; the likelihood of I [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 1-12] being discotic mesogens was determined by mol. mechanics calculations and compared to the behavior of the prepared compounds I [R = 4-H(CH₂)_nOC₆H₄; n = 1-8] were predicted to be liquid crystals, while the behaviors of I [R = 4-Me(CH₂)_nOC₆H₄; n = 9-12] were not clear from the calculations; I (4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph) were predicted not to be liquid crystals. The m.ps., glass and phase transition temperatures, and heats of melting, crystallization, and phase transition for I [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 3, 4, 6, 9, 12] were determined

Russian Journal of General Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Alam, Todd M. published the artcileDynamic heterogeneity and nanophase separation in rubber-toughened amine-cured highly cross-linked polymer networks, Related Products of quinuclidine, the publication is Polymer Testing (2022), 107616, database is CAplus.

Solid state NMR spectroscopy and small-to wide-angle X-ray scattering (SWAXS) methods were used to characterize the heterogeneous dynamics and polymer domain structure in rubber modified thermoset materials containing the diglycidyl ether of bisphenol A (DGEBA) epoxy resin and a mixture of Jeffamine reactive rubber and 4,4-diaminodicyclohexylmethane (PACM) amine curing agent. The polymer chain dynamics and morphologies as a function of the PACM/Jeffamine ratio were determined Using dipolar-filtered NMR experiments, the resulting networks are shown to be composed of mobile and rigid regions that are separated on nanometer length scales, along with a dynamically immobilized interface region. Proton NMR spin diffusion experiments measured the dimensions of the mobile phase to range between 9 and 66 nm and varied with the relative PACM concentration Solid state ¹³C magic angle spinning NMR experiments show that the highly mobile phase is composed entirely of the dynamically flexible polyether chains of the Jeffamine rubber, the immobilized interface region is a mixture of DGEBA, PACM, and the Jeffamine rubber, with the PACM crosslinked to DGEBA predominantly residing in the rigid phase. The SWAXS results showed compositional nanophase separation spanning the 11-77 nm range. These measurements of the nanoscale compositional and dynamic heterogeneity provide mol. level insight into the very broad and controllable glass transition temperature distributions observed for these highly crosslinked polymer networks.

Polymer Testing published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

McNelles, Stuart A. published the artcileRapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne-Azide Cycloaddition, Formula: C19H15NO3, the publication is Macromolecules (Washington, DC, United States) (2017), 50(20), 7993-8001, database is CAplus.

Preparation of structurally perfect high-generation dendrimer libraries with different peripheral groups is challenging as divergent synthesis introduces peripheral defects and convergent synthesis leads to low yields. Here, we prepare a third-generation polyester dendron based on the bisMPA monomer structure, having eight peripheral azide functionalities, as an “inner” dendron. We also prepare a series of low-generation “outer” dendrons (G2 and G3) with various peripheral groups, including aromatic, aliphatic, and polar structures, each having a single dibenzoazacyclooctyne (DIBAC) at the core. Efficient strain-promoted azide-alkyne cycloaddition (SPAAC) enables quant. coupling between the outer and inner dendrons, producing high-generation (G5 and G6) dendrimers in a single coupling step. Characterization by NMR and mass spectrometry shows that the coupling products are structurally perfect. Using this strategy, we prepared a small dendrimer library that includes the first high-generation monodisperse peripherally PEGylated dendrimers as well as a structure bearing bulky protected amino acids at its periphery. This general strategy allows for rapid, efficient, and quant. preparation of high-generation dendrimers with a variety of peripheral and core functional groups, starting from small, easily prepared fragments.

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sakurai, Yu published the artcileTargeted delivery of lipid nanoparticle to lymphatic endothelial cells via anti-podoplanin antibody, SDS of cas: 1353016-70-2, the publication is Journal of Controlled Release (2022), 379-387, database is CAplus and MEDLINE.

Lymphatic endothelial cells (LECs) that form lymphatic vessels play a pivotal role in immune regulation. It was recently reported that LECs suppress the antigen-dependent anti-tumor immunity in cancer tissues. Thus, regulating the function of LECs is a promising strategy for cancer therapy. The objective of this study was to develop a method for the selective delivery of small interfering RNA (siRNA) to LECs. For this purpose, the siRNA was formulated into nanoparticles (LNPs) to prevent them from being degraded in body fluids and to facilitate their penetration of the cell membrane. A breakthrough technol. for achieving this is ONPATTRO, a worlds first siRNA drug. Since LNPs are taken up by hepatocytes relatively well via low-d. lipoprotein receptors, most of the LNP systems that have been developed so far target hepatocytes. In this study, we report on the development of a new method for the rapid and convenient method for modifying LNPs with antibodies using the CLick reaction on the Interface of the nanoParticle (CLIP). The CLIP approach was faster and more versatile than the conventional method using amide coupling. As a demonstration, we report on the LEC-targeted siRNA delivery by using antibody-modified LNPs both in vitro and in vivo. The method used for the modification of LNPs is highly promising and has the potential for expanding the LNP-based delivery of nucleic acids in the future.

Journal of Controlled Release published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Gholivand, Khodayar published the artcileSynthesis and crystal structure of phosphonic acid and bisphosphoramidate derivatives: QSAR studies of their anti-fungal potential on Macrophomina Phaseolina (Tassi) Goid, Application In Synthesis of 1761-71-3, the publication is Journal of the Iranian Chemical Society (2021), 18(7), 1591-1606, database is CAplus.

Abstract: A series of phosphonic acid and bisphosphoramidate derivatives were synthesized and characterized. The bioactivities against the fungal pathogen Macrophomina phaseolina and human acetylcholinesterase AChE enzyme were studied using QSAR based on multiple linear regression. L17, with (p-Cl-C6H4-NH) (p-Cl-C6H4)C(H)P(O)(OC2H5)2 skeleton, demonstrated a great mortality on the M. phaseolina mycelial growth by 83% inhibition at 150 mg/L; the other tested derivative showed moderate to weak antifungal activity against the fungus. QSAR model based on the GA-MLR method revealed the importance of 3D descriptors (De, Mor18e, H8m, and Mor30p) on the antifungal activity. It showed good capability in predicting the fungicidal activity of the studied mols. Another derivative, L5, with (m-CH3-NC5H4-NH)(m-CH3-C6H4)C(H)P(O)(OCH3)2 skeleton displays the most potent anti-AChE activity. The electronic parameters, ΔEL-H, and ELUMO, have the highest contribution of human AChE. The authors suggest that these models could be usefully employed in designing more effective crop protection compounds without side effects on non-target organisms.

Journal of the Iranian Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider